Hongbing Fan

Mar 12, 2024 | dx.doi.org | Zihan Wang |Hongbing Fan |Jianping Wu |Kenneth H. III

Angiotensin converting enzyme 2 (ACE2), best known as the entry receptor of the pandemic’s severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has attracted considerable attention during the outbreak of COVID-19. (1) ACE2 was first discovered in 2000 from a human cardiac left ventricle cDNA library.

Mar 12, 2024 | pubs.acs.org | Zihan Wang |Hongbing Fan |Jianping Wu |Kenneth H. III

Angiotensin converting enzyme 2 (ACE2), best known as the entry receptor of the pandemic’s severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has attracted considerable attention during the outbreak of COVID-19. (1) ACE2 was first discovered in 2000 from a human cardiac left ventricle cDNA library.

Feb 14, 2024 | onlinelibrary.wiley.com | Hongbing Fan |Nan Shang |Sandra Davidge |Jianping Wu

This study aims to investigate the antihypertensive effect of four chicken muscle-derived angiotensin (Ang)-converting enzymes (ACE)-regulating peptides: Val-Arg-Pro (VRP, ACE inhibition), Leu-Lys-Tyr and Val-Arg-Tyr (LKY and VRY, ACE inhibition and ACE2 upregulation), and Val-Val-His-Pro-Lys-Glu-Ser-Phe (VVHPKESF [V-F], ACE2 upregulation) in spontaneously hypertensive rats. Rats (12–14 weeks old) are grouped: 1) untreated, 2) VRP, 3) LKY, 4) VRY, and 5) V-F.

Mar 2, 2023 | mdpi.com | Shuguang Wang |Mouming Zhao |Jianping Wu |Hongbing Fan

Abstract:The demand for plant-based meat analogs (PBMA) is on the rise as a strategy to sustain the food protein supply while mitigating environmental change. In addition to supplying essential amino acids and energy, food proteins are known sources of bioactive peptides. Whether protein in PBMA affords similar peptide profiles and bioactivities as real meat remains largely unknown.