Hongbo Hu

Nov 19, 2024 | nature.com | Weiqi Hong |Aqu Alu |Zimin Chen |Hongbo Hu |Haohao Dong |Jian Lei | +8 more

AbstractThe mucosal immune response plays a crucial role in the prevention of respiratory viruses. Given the risk of recurrent SARS-CoV-2 infections in the population, the rapid development of next-generation intranasal COVID-19 vaccines with high safety and efficacy is paramount. In the current study, we developed a protein-based intranasal vaccine comprising the XBB.1.5 receptor binding domain (RBD)-derived trimeric recombinant protein (RBDXBB.1.5-HR) and an MF59-like oil-in-water adjuvant.

Sep 23, 2024 | 4spepublications.onlinelibrary.wiley.com | Chi Zhang |Hongbo Hu |Yang Liu |Kunkun Zhu

CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1, , , et al. The opportunities and challenges of hybrid composite driveshafts and their couplings in the aerospace industry: a review. Compos Struct. 2023; 320:117203. doi:10.1016/j.compstruct.2023.117203 2, , , et al. Recent advances in carbon-fiber reinforced thermoplastic composites: a review. Compos Part B. 2017; 142: 241-250. doi:10.1016/j.compositesb.2017.12.007 3, , , et al.

Jan 14, 2024 | nature.com | Huiyuan Zhang |Hongbo Hu

Millions of cells undergo daily cell death, a process essential for maintaining physiological homeostasis and pathogenesis. Various forms of cell death, such as apoptosis, necroptosis, ferroptosis and pyroptosis, have been extensively studied for their distinct biological functions [1, 2]. Generally, programmed cell death, like apoptosis, is considered physiological and results in little to no inflammatory response. In contrast, lytic cell death tends to be inflammatory [3].