Jian Lei

Nov 19, 2024 | nature.com | Weiqi Hong |Aqu Alu |Zimin Chen |Hongbo Hu |Haohao Dong |Jian Lei | +8 more

AbstractThe mucosal immune response plays a crucial role in the prevention of respiratory viruses. Given the risk of recurrent SARS-CoV-2 infections in the population, the rapid development of next-generation intranasal COVID-19 vaccines with high safety and efficacy is paramount. In the current study, we developed a protein-based intranasal vaccine comprising the XBB.1.5 receptor binding domain (RBD)-derived trimeric recombinant protein (RBDXBB.1.5-HR) and an MF59-like oil-in-water adjuvant.

May 16, 2024 | ehp.niehs.nih.gov | Lu Zhou |Cong Liu |Jian Lei |Yixiang Zhu

: Environmental Health Perspectives Volume 132, Issue 5 CID: 057005 Introduction External causes of injury, including transportation-related injuries, self-harm, falls, and other injuries, are significant causes of death, particularly among young and middle-aged individuals.1–3 According to the global burden of disease (GBD) study,2 injuries caused about 249 million disability-adjusted life-years (DALYs) in 2019, with a high incidence and prevalence in the working-age population,4 leading to...