Hongchao Guo

Oct 31, 2024 | biorxiv.org | Chad S. Weldy |Qin Li |Joao Monteiro |Hongchao Guo

AbstractMapping the genomic architecture of complex disease has been predicated on the understanding that genetic variants influence disease risk through modifying gene expression. However, recent discoveries have revealed that a significant burden of disease heritability in common autoinflammatory disorders and coronary artery disease is mediated through genetic variation modifying post-transcriptional modification of RNA through adenosine-to-inosine (A-to-I) RNA editing.

Jul 11, 2024 | biorxiv.org | Chad S. Weldy |Qin Li |Joao Monteiro |Hongchao Guo

AbstractMapping the genomic architecture of complex disease has been predicated on the understanding that genetic variants influence disease risk through modifying gene expression. However, recent discoveries have revealed that a significant burden of disease heritability in common autoinflammatory disorders and coronary artery disease is mediated through genetic variation modifying post-transcriptional modification of RNA through adenosine-to-inosine (A-to-I) RNA editing.

Jun 10, 2024 | pubs.rsc.org | Yue Ren |Wangyu Shi |Yi Tang |Hongchao Guo

Phosphine-Catalyzed (3+3) Annulation of Cinnamaldehyde-Derived Morita-Baylis-Hillman Carbonates with Dinucleophiles The phosphine-catalyzed (3+3) annulation reaction of cinnamaldehyde-derived Morita-Baylis-Hillman (MBH) carbonates with 1,3-dicarbonyl compounds as dinucleophiles has been developed, giving hexahydrochromenone derivatives in high yields with moderate to good diastereoselectivities.

Feb 5, 2024 | thieme-connect.com | Leijie Zhou |Hongchao Guo

Buy Article Permissions and Reprints All articles of this category Nucleophilic phosphine-catalyzed annulations are recognized as practical and powerful tools for synthesizing various cyclic compounds. Phosphine acceptors play a key role in nucleophilic phosphine catalysis. The design and synthesis of new phosphine acceptors that are able to introduce new zwitterionic intermediates with new reactivities into phosphine-catalyzed annulations is highly desirable.

Jan 7, 2024 | preprints.org | Jieni Li |Fei Xie |Hongchao Guo

Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 5 January 2024 / Approved: 5 January 2024 / Online: 8 January 2024 (01:19:39 CET) Li, J.; Xie, F.; Guo, H. A Statistical Model for Identifying Collusive Bidding Based on Historical Quotations. Preprints 2024, 2024010487. https://doi.org/10.20944/preprints202401.0487.v1 Li, J.; Xie, F.; Guo, H. A Statistical Model for Identifying Collusive Bidding Based on Historical Quotations. Preprints 2024, 2024010487.