Chad S. Weldy

Oct 31, 2024 | biorxiv.org | Chad S. Weldy |Qin Li |Joao Monteiro |Hongchao Guo

AbstractMapping the genomic architecture of complex disease has been predicated on the understanding that genetic variants influence disease risk through modifying gene expression. However, recent discoveries have revealed that a significant burden of disease heritability in common autoinflammatory disorders and coronary artery disease is mediated through genetic variation modifying post-transcriptional modification of RNA through adenosine-to-inosine (A-to-I) RNA editing.

Jul 11, 2024 | biorxiv.org | Chad S. Weldy |Qin Li |Joao Monteiro |Hongchao Guo

AbstractMapping the genomic architecture of complex disease has been predicated on the understanding that genetic variants influence disease risk through modifying gene expression. However, recent discoveries have revealed that a significant burden of disease heritability in common autoinflammatory disorders and coronary artery disease is mediated through genetic variation modifying post-transcriptional modification of RNA through adenosine-to-inosine (A-to-I) RNA editing.

May 25, 2023 | biorxiv.org | Chad S. Weldy |Wenduo Gu |Albert J Pedroza

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