Chad S. Weldy

1 month ago | biorxiv.org | Chad S. Weldy |Soumya Kundu |Joao Monteiro |Wenduo Gu

AbstractVascular sites have distinct susceptibility to atherosclerosis and aneurysm, yet the biological underpinning of vascular site-specific disease risk is largely unknown. Vascular tissues have different developmental origins that may influence global chromatin accessibility, and understanding differential chromatin accessibility, gene expression profiles, and gene regulatory networks (GRN) on single cell resolution may give key insight into vascular site-specific disease risk.

Oct 31, 2024 | biorxiv.org | Chad S. Weldy |Qin Li |Joao Monteiro |Hongchao Guo

AbstractMapping the genomic architecture of complex disease has been predicated on the understanding that genetic variants influence disease risk through modifying gene expression. However, recent discoveries have revealed that a significant burden of disease heritability in common autoinflammatory disorders and coronary artery disease is mediated through genetic variation modifying post-transcriptional modification of RNA through adenosine-to-inosine (A-to-I) RNA editing.

Jul 11, 2024 | biorxiv.org | Chad S. Weldy |Qin Li |Joao Monteiro |Hongchao Guo

AbstractMapping the genomic architecture of complex disease has been predicated on the understanding that genetic variants influence disease risk through modifying gene expression. However, recent discoveries have revealed that a significant burden of disease heritability in common autoinflammatory disorders and coronary artery disease is mediated through genetic variation modifying post-transcriptional modification of RNA through adenosine-to-inosine (A-to-I) RNA editing.