Hongming Chen

Jan 21, 2025 | nature.com | Yongzhi Lu |Qi Yang |Ting Ran |Wei Zhang |Deyin Guo |Xinwen Chen | +1 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-024-54462-0, published online 23 November 2024In this article there is an error in Figure 1 where the residue labelling incorrectly read E164 and should be D164. The original article has been corrected.

Nov 22, 2024 | nature.com | Yongzhi Lu |Qi Yang |Ting Ran |Wei Zhang |Deyin Guo |Xinwen Chen | +1 more

AbstractThe RNA-dependent RNA polymerase (RdRp), 3C-like protease (3CLpro), and papain-like protease (PLpro) are pivotal components in the viral life cycle of SARS-CoV-2, presenting as promising therapeutic targets. Currently, all FDA-approved antiviral drugs against SARS-CoV-2 are RdRp or 3CLpro inhibitors. However, the mutations causing drug resistance have been observed in RdRp and 3CLpro from SARS-CoV-2, which makes it necessary to develop antivirals with novel mechanisms.

Mar 19, 2024 | mdpi.com | Hongming Chen |Dan Zhou

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Nov 7, 2023 | propertyweek.com | Hongming Chen

Moving industrial and manufacturing facilities to countries with lower labour costs has long been seen as a convenient way for Western brands to keep the quality of products high while reducing costs. It has been so successful that very little of what is bought by Western consumers is produced on home turf any more. However, even before Covid-19, a political shift was taking place in countries worldwide, particularly in the UK and US, with a growing desire to bring jobs closer to home.

Aug 15, 2023 | arxiv.org | Hongming Chen |Yufeng Li

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