Hongwei Zhou

Jan 8, 2025 | nature.com | Hongwei Zhou

Mar 27, 2024 | dx.doi.org | Ying Chen |Yiyang Zhang |Hongwei Zhou |Lei Yu

Jun 7, 2023 | nature.com | Kai Sun |Hongwei Zhou

AbstractSecreted proteins are one of the direct molecular mechanisms by which microbiota influence the host, thus constituting a promising field for drug discovery. Here, through bioinformatics-guided screening of the secretome of clinically established probiotics from Lactobacillus, we identify an uncharacterized secreted protein (named LPH here) that is shared by most of these probiotic strains (8/10) and demonstrate that it protects female mice from colitis in multiple models.

Jun 2, 2023 | nature.com | Cynthia Rodriguez |Hongwei Zhou |Julien Tap

AbstractNext generation amplicon sequencing has created a plethora of data from human microbiomes. The accessibility to this scientific data and its corresponding metadata is important for its reuse, to allow for new discoveries, verification of published results, and serving as path for reproducibility. Dietary fiber consumption has been associated with a variety of health benefits that are thought to be mediated by gut microbiota.