Lei Yu

2 months ago | digitalcommons.library.tmc.edu | Aron S. Buchman |Lei Yu |Shahram Oveisgharan |Andrea R. Zammit

BACKGROUND: The interrelationship of parkinsonism, Parkinson's disease (PD) and other Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD) pathologies is unclear. OBJECTIVE: We examined the progression of parkinsonian signs in adults with and without parkinsonism, and their underlying brain pathologies. METHODS: Annual parkinsonian signs were based on a modified Unified Parkinson's Disease Rating Scale.

Oct 13, 2024 | mdpi.com | Qian Su |Lei Yu

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Aug 8, 2024 | mdpi.com | Zeyu Xu |Ming Yang |Lei Yu

1. IntroductionUrbanization leads to many environmental problems, among which noise is a major one [1]. In European Union countries, about 20% of the population suffers from noise levels above 65 dB [2] and this is more serious in developing countries. Recently, with the rapid increase in automobiles, noise has become the top environmental complaint in China’s metropolises (e.g., Shenzhen) [3]. In comparison to other environmental problems, the effect of noise is greater in high-density cities.

Jun 21, 2024 | onlinelibrary.wiley.com | Lei Yu |Jing Li |Mingyang Zhang |Yu Li

1 INTRODUCTION RFC4 is necessary for DNA polymerase δ and DNA polymerase ε to extend primed DNA templates. The RFC family functions as clamp loaders during DNA synthesis, loading PCNA onto DNA through an ATP-dependent process.1-3 During the S phase of DNA replication, RFCs activate polymerase assembly and cell cycle checkpoint control. Upon DNA damage, they activate their mismatch and excision repair mechanisms after forming complexes with PCNA.

May 14, 2024 | nature.com | Shahram Oveisgharan |Lei Yu |Vladislav A. Petyuk |Ricardo Assunção Vialle |Vilas Menon

AbstractAccumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected. Here, we use data of 1206 elders and test that RNA expression levels of GPER1, a transmembrane protein, modify the association of Aβ with tau tangles. GPER1 RNA expression is related to more tau tangles (p = 0.001).