Hongyang Wang

Sep 26, 2024 | nature.com | Hongyang Wang

AbstractTumor microenvironment heterogeneity in hepatocellular carcinoma (HCC) on a spatial single-cell resolution is unclear. Here, we conducted co-detection by indexing to profile the spatial heterogeneity of 401 HCC samples with 36 biomarkers. By parsing the spatial tumor ecosystem of liver cancer, we identified spatial patterns with distinct prognosis and genomic and molecular features, and unveiled the progressive role of vimentin (VIM)high macrophages.

Jul 18, 2024 | arxiv.org | Hongyang Wang

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Jun 25, 2024 | link.aps.org | Yi Tao |Ting Chen |Hongyang Wang |Jie Zhang

Abstract In a trapped-ion system, accurate thermometry of ions is crucial for precisely evaluating the system state and performing quantum operations. However, when the motional state of a single ion is far away from the ground state, the spatial dimensionality of the phonon state sharply increases. Then it is difficult to realize accurate and mode-resolved thermometry with existing methods.

Jan 4, 2024 | nature.com | Hongyang Wang

AbstractInduction of tumor vascular normalization is a crucial measure to enhance immunotherapy efficacy. cGAS-STING pathway is vital for anti-tumor immunity, but its role in tumor vasculature is unclear. Herein, using preclinical liver cancer models in Cgas/Sting-deficient male mice, we report that the interdependence between tumor cGAS and host STING mediates vascular normalization and anti-tumor immune response.