Ting Chen

1 month ago | nature.com | Jinming Cheng |Fusheng Guo |Felicity C. Jackling |Jicheng Yang |Jonathan Tan |Nick Barker | +14 more

Hair follicles cycle through expansion, regression and quiescence. To investigate the role of MCL‑1, a BCL‑2 family protein with anti‑apoptotic and apoptosis‑unrelated functions, we delete Mcl‑1 within the skin epithelium using constitutive and inducible systems. Constitutive Mcl‑1 deletion does not impair hair follicle organogenesis but leads to gradual hair loss and elimination of hair follicle stem cells. Acute Mcl‑1 deletion rapidly depletes activated hair follicle stem cells and completely blocks depilation‑induced hair regeneration in adult mice, while quiescent hair follicle stem cells remain unaffected. Single‑cell RNA‑seq profiling reveals the engagement of P53 and DNA mismatch repair signaling in hair follicle stem cells upon depilation‑induced activation. Trp53 deletion rescues hair regeneration defects caused by acute Mcl‑1 deletion, highlighting a critical interplay between P53 and MCL‑1 in balancing proliferation and death. The ERBB pathway plays a central role in sustaining the survival of adult activated hair follicle stem cells by promoting MCL‑1 protein expression. Remarkably, the loss of a single Bak allele, a pro‑apoptotic Bcl‑2 effector gene, rescues Mcl‑1 deletion‑induced defects in both hair follicles and mammary glands. These findings demonstrate the pivotal role of MCL‑1 in inhibiting proliferation stress‑induced apoptosis when quiescent stem cells activate to fuel tissue regeneration. Here the authors unveil the essential role of MCL-1 for adult hair follicle regeneration and inhibition of proliferation stress-induced apoptosis in mice. They also identify a P53/MCL-1/BAK axis balancing proliferation and death of activated hair follicle stem cells to ensure proper hair growth.

Jan 16, 2025 | mdpi.com | Ting Chen |Ting Huang |Jinhai Shen |Moudan Ye

1. Introduction3,4-Dihydroquinazoline is a versatile nitrogen-containing heterocyclic scaffold found in many bioactive compounds with diverse biological activities (Figure 1). For example, vasicine (I), a natural alkaloid from Adhatoda vasica, exhibits various bioactivities [1,2,3].

Jan 9, 2025 | onlinelibrary.wiley.com | Ting Chen |Xueping Li |Yi Li |Lu Zhang

1 Introduction Hepatocellular carcinoma (HCC) ranks as the sixth most commonly diagnosed cancer and the third leading cause of cancer-related mortality worldwide.[1] Due to the insidious nature of HCC, most patients are often diagnosed at advanced stages and are only eligible to systemic treatments.[2] Despite the evolution of molecular-targeted therapy and immunotherapy has dramatically changed the systemic treatment landscape of advanced HCC, the overall response is still limited by the...

Jan 7, 2025 | pubs.rsc.org | Ting Chen |Syrine Mahdadi

Comment on “l-Proline-promoted three-component reaction of anilines, aldehydes and barbituric acids/malononitrile: regioselective synthesis of 5-arylpyrimido[4,5-b]quinoline-diones and 2-amino-4-arylquinoline-3-carbonitriles in water” by A. Khalafi-Nezhad, S. Sarikhani, E. Shaikhi Shahidzadeh and F.

Dec 23, 2024 | pubs.rsc.org | Ting Chen

A rapid and highly sensitive fluorescence immunochromatographic test strip for pepsin detection in human hypopharyngeal saliva Pepsin serves as a potential biomarker for laryngopharyngeal reflux disease (LPRD). The reported methods for detecting pepsin still have limitations, such as long reaction times and low sensitivity. Therefore, it is crucial to develop a rapid, simple and sensitive detection method.