Hongyu Lu

Oct 11, 2024 | elifesciences.org | Ting Liu |Xing Shen |Yijia Ren |Hongyu Lu

eLife assessment This study describes a useful antibody-free method to map both G-quadruplexes and R-loops in vertebrate cells independently of the BG4 and S9.6 antibodies. It also reveals that the helicase Dhx9 can affect the self-renewal and differentiation capacities of mESCs, perhaps by regulating co-localized G4s and R-loops.

Jun 4, 2024 | biorxiv.org | Ting Liu |Xing Shen |Yijia Ren |Hongyu Lu

AbstractThe non-B DNA structures can act as dynamic functional genomic elements regulating gene expression. Among them, G4s and R-loops are two of the best studied. The interplay between R-loops and G4s are emerging in regulating DNA repair, replication and transcription. A comprehensive picture of native co-localized G4s and R-loops in living cells is currently lacking.

Oct 8, 2023 | dx.doi.org | Yang Lu |Yixin Ma |Jiang Zhu |Hongyu Lu

Zirconia (ZrO2) is an excellent host material in the luminescent materials field because of its low phonon energy. Nevertheless, owing to a very high melting point of 2715 °C, preparation of cubic ZrO2 by the solid-state reaction must be done at high temperatures (>1400 °C).