Hsueh-Han Lu

1 month ago | nature.com | Hsueh-Han Lu |Qin Li |Alex Clark |Aaron F. Garretson |Sven Heinz |Aaron Carlin

AbstractUnderstanding flavivirus immunity is critical for the development of pan-flavivirus vaccines. Dendritic cells (DC) coordinate antiviral innate and adaptive immune responses, and they can be targeted by flaviviruses as a mechanism of immune evasion.

Dec 5, 2023 | nature.com | Stephanie Collins |Pedro Belda-Ferre |Hsueh-Han Lu |Julian Avila-Pacheco |Damian R. Plichta |Mingxun Wang | +9 more

AbstractDetermining the structure and phenotypic context of molecules detected in untargeted metabolomics experiments remains challenging. Here we present reverse metabolomics as a discovery strategy, whereby tandem mass spectrometry spectra acquired from newly synthesized compounds are searched for in public metabolomics datasets to uncover phenotypic associations.