Damian R. Plichta

Sep 18, 2024 | nature.com | Munehiro Furuichi |Takaaki Kawaguchi |Keiko Yasuma-Mitobe |Damian R. Plichta |Masahiro Ueda |Nobuyuki Okahashi | +10 more

AbstractPersistent colonization and outgrowth of potentially pathogenic organisms in the intestine can result from long-term antibiotic use or inflammatory conditions, and may perpetuate dysregulated immunity and tissue damage1,2. Gram-negative Enterobacteriaceae gut pathobionts are particularly recalcitrant to conventional antibiotic treatment3,4, although an emerging body of evidence suggests that manipulation of the commensal microbiota may be a practical alternative therapeutic strategy5,6,7.

Dec 5, 2023 | nature.com | Stephanie Collins |Pedro Belda-Ferre |Hsueh-Han Lu |Julian Avila-Pacheco |Damian R. Plichta |Mingxun Wang | +9 more

AbstractDetermining the structure and phenotypic context of molecules detected in untargeted metabolomics experiments remains challenging. Here we present reverse metabolomics as a discovery strategy, whereby tandem mass spectrometry spectra acquired from newly synthesized compounds are searched for in public metabolomics datasets to uncover phenotypic associations.