Huayun Shi

Oct 1, 2024 | pubs.rsc.org | Huayun Shi |Guy J Clarkson |Peter J. Sadler

Tuning the phototherapeutic activity of Pt(iv) complexes for bladder cancer via modification of trans N-heterocyclic ligands† Bladder cancer is a common cancer globally that suffers from expensive treatment, drug and hypoxia resistance, and high recurrence rate.

Apr 24, 2024 | onlinelibrary.wiley.com | Huayun Shi |Fortuna Ponte |Cinzia Imberti |Miguel A. Gomez-Gonzalez

Introduction Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) offer two important cancer treatment modalities as phototherapy, in which light is applied to activate prodrugs to improve selectivity for cancer versus normal cells.1 PDT agents are oxygen-dependent, generating 1O2 and other reactive oxygen species (ROS), and are already used in the clinic.1d, 2 Oxygen-independent PACT agents form active species by chemical changes upon irradiation, but are still under...