Hubei Univeristy

Nov 24, 2023 | frontiersin.org | Hubei Univeristy |Rakesh Kapoor |Alessandro Boscarelli |Nicholas Pavlidis

IntroductionThe incidence of multiple primary cancers (MPC) has shown an upward trend in the general population (1), accounting for approximately 1-16% of all cancer cases (2, 3). The etiology of MPC was found to be multifactorial, involving factors, such as genetic predisposition, environmental exposures, and lifestyle choices. The presence of MPC complicates the diagnostic process, treatment plan formulation, and prognosis assessment, and no unified standard was established.

Aug 18, 2023 | frontiersin.org | Chandra M. Goparaju |Xiaohong Li |Kazuhiro Yoshimura |Hubei Univeristy

IntroductionTumor-to-tumor metastasis (TTM), also known as tumor collision, is a rare event in which one primary tumor metastasizes to another distinct primary tumor (1). The TTM incidence is 0.2%–3.5% in autopsy series, which indicates its rarity (2). The TTM pathophysiology is not yet completely understood, but several theories have been proposed.