Huiqin Chen

Aug 6, 2024 | cell.com | Huiqin Chen |Xiaofei Ge |Chun Li |Jianwei Zeng

Interleukin (IL)-12 is a heterodimeric pro-inflammatory cytokine. Our cryoelectron microscopy structure determination of human IL-12 in complex with IL-12Rβ1 and IL-12Rβ2 at a resolution of 3.75 Å reveals that IL-12Rβ2 primarily interacts with the IL-12p35 subunit via its N-terminal Ig-like domain, while IL-12Rβ1 binds to the p40 subunit with its N-terminal fibronectin III domain.

Jul 27, 2023 | mdpi.com | Yang Luo |Huiqin Chen |Mingzhen Gui

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticlebyYang Luo 1, Huiqin Chen 2 and Mingzhen Gui 3,* 1Department of Neurology, Xiangya Hospital, Central South University, Changsha 410083, China2Department of Radiology, Xiangya Hospital, Central South University, Changsha 410083, China3School of Automation, Central South University, Changsha 410083, China*Author to whom correspondence should be addressed.