Jianwei Zeng

Aug 6, 2024 | cell.com | Huiqin Chen |Xiaofei Ge |Chun Li |Jianwei Zeng

Interleukin (IL)-12 is a heterodimeric pro-inflammatory cytokine. Our cryoelectron microscopy structure determination of human IL-12 in complex with IL-12Rβ1 and IL-12Rβ2 at a resolution of 3.75 Å reveals that IL-12Rβ2 primarily interacts with the IL-12p35 subunit via its N-terminal Ig-like domain, while IL-12Rβ1 binds to the p40 subunit with its N-terminal fibronectin III domain.

Jul 7, 2024 | nature.com | Laixing Zhang |Hao Wang |Jianwei Zeng |Zhengyu Gao |Jiawei Wang |Yi Zhang | +1 more

AbstractClustered regularly interspaced short palindromic repeats (CRISPR)–Cas systems are prokaryotic adaptive immune systems against invading phages and other mobile genetic elements. Notably, some phages, including the Vibrio cholerae-infecting ICP1 (International Center for Diarrheal Disease Research, Bangladesh cholera phage 1), harbor CRISPR–Cas systems to counteract host defenses.