Huixia Ren

Jul 13, 2024 | nature.com | Jia Zhao |Huixia Ren |Chao Tang |Liangyi Chen |Yanmei Liu |Francis C. Lynn | +1 more

AbstractRemarkable advances in protocol development have been achieved to manufacture insulin-secreting islets from human pluripotent stem cells (hPSCs). Distinct from current approaches, we devised a tunable strategy to generate islet spheroids enriched for major islet cell types by incorporating PDX1+ cell budding morphogenesis into staged differentiation.