Liangyi Chen

Sep 13, 2024 | nature.com | Shu Wang |Feng Huang |Liangyi Chen

AbstractDiagnostic pathology, historically dependent on visual scrutiny by experts, is essential for disease detection. Advances in digital pathology and developments in computer vision technology have led to the application of artificial intelligence (AI) in this field. Despite these advancements, the variability in pathologists’ subjective interpretations of diagnostic criteria can lead to inconsistent outcomes.

Jul 13, 2024 | nature.com | Jia Zhao |Huixia Ren |Chao Tang |Liangyi Chen |Yanmei Liu |Francis C. Lynn | +1 more

AbstractRemarkable advances in protocol development have been achieved to manufacture insulin-secreting islets from human pluripotent stem cells (hPSCs). Distinct from current approaches, we devised a tunable strategy to generate islet spheroids enriched for major islet cell types by incorporating PDX1+ cell budding morphogenesis into staged differentiation.