Hye Ryun

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Pragmatic nationwide master observational trial based on genomic alterations in advanced solid tumors: KOrean Precision Medicine Networking Group Study of MOlecular profiling guided therapy based on genomic alterations in advanced Solid tumors (KOSMOS)-II

May 9, 2024 | bmccancer.biomedcentral.com | Sun Young |Jee Hyun |Hye Ryun |Sook Ryun

The KOSMOS-II trial comprises a framework for screening patients with actionable targets, operating a cMTB that recommends and provides MGT, and developing a clinico-genomic database (CGDB). MGT options include TUID with targeted and/or immunotherapies (Tier 1); local practice involving therapy within or outside the approved indications (Tier 2); or participation in clinical trials (Tier 3) (Fig. 1). Study Scheme for KOSMOS-II trial.

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