Hyun-Ji Park

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Articles

Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma

Mar 3, 2023 | science.org | Ananth Balashankar |Hyun-Ji Park |Ziv Epstein |Jordan F. Hastings

AbstractGene expression noise is known to promote stochastic drug resistance through the elevated expression of individual genes in rare cancer cells. However, we now demonstrate that chemoresistant neuroblastoma cells emerge at a much higher frequency when the influence of noise is integrated across multiple components of an apoptotic signaling network.
The catheterized bladder environment promotes Efg1- and Als1-dependent Candida albicans infection

Mar 3, 2023 | science.org | Ananth Balashankar |Hyun-Ji Park |Ziv Epstein |Marissa Jeme Andersen

AbstractCatheter-associated urinary tract infections (CAUTIs) account for 40% of hospital-acquired infections (HAIs). As 20 to 50% of hospitalized patients receive catheters, CAUTIs are one of the most common HAIs, resulting in increased morbidity, mortality, and health care costs. Candida albicans is the second most common CAUTI uropathogen, yet relative to its bacterial counterparts, little is known about how fungal CAUTIs are established.
Embedment of sensing elements for robust, highly sensitive, and cross-talk-free iontronic skins for robotics applications

Mar 3, 2023 | science.org | Ananth Balashankar |Hyun-Ji Park |Ziv Epstein

Toughening and strengthening effect of the embedded configurationThe embedded hole array has a toughening and strengthening effect that helps improve the mechanical stability of the iontronic skin.
Predicting the environmental fates of emerging contaminants: Synergistic effects in ozone reactions of nitrogen-containing alkenes

Mar 3, 2023 | science.org | Ananth Balashankar |Hyun-Ji Park |Ziv Epstein |Lisa M. Wingen

Product measurementsSolutions of O3 and the model compounds or NPM in CCl4 were mixed rapidly in a 25-ml round-bottom flask. The use of higher than ambient ozone concentrations could affect the distribution of products if, for example, ozone reacts rapidly with Criegee intermediates or initially formed products.
Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative

Mar 3, 2023 | science.org | Ananth Balashankar |Hyun-Ji Park |Ziv Epstein |Eva Pauwels

LATEST NEWS AbstractDuring cotranslational translocation, the signal peptide of a nascent chain binds Sec61 translocon to initiate protein transport through the endoplasmic reticulum (ER) membrane.
Social media: Why sharing interferes with telling true from false

Mar 3, 2023 | science.org | Ananth Balashankar |Hyun-Ji Park |Ziv Epstein |Valerie Reyna

From the invention of the printing press to direct-to-consumer drug advertising, the democratization of information is a long-term trend (1). Today’s technology allows the public to access an abundance of information and the onus is increasingly on them to use it to make decisions, as in patient-centered medical decisions (2).
A molecular framework for grain number determination in barley

Mar 3, 2023 | science.org | Ananth Balashankar |Hyun-Ji Park |Ziv Epstein |Iris Hoffie

LATEST NEWS AbstractFlowering plants with indeterminate inflorescences often produce more floral structures than they require. We found that floral primordia initiations in barley (Hordeum vulgare L.) are molecularly decoupled from their maturation into grains.
Hierarchical approaches to Text-based Offense Classification

Mar 3, 2023 | science.org | Ananth Balashankar |Hyun-Ji Park |Ziv Epstein |Jay Choi

Offense description dataTo generate the TOC model, we pool two sources of hand-coded offense description information and caseload count data from Measures for Justice (MFJ) and the CJARS. MFJ is a nonpartisan nonprofit with a mission to make reliable criminal justice system data available at the county level to spur dialog and reform.
Cryo-EM structures of human SPCA1a reveal the mechanism of Ca2+/Mn2+ transport into the Golgi apparatus

Mar 3, 2023 | science.org | Ananth Balashankar |Hyun-Ji Park |Ziv Epstein

LATEST NEWS AbstractSecretory pathway Ca2+/Mn2+ ATPase 1 (SPCA1) actively transports cytosolic Ca2+ and Mn2+ into the Golgi lumen, playing a crucial role in cellular calcium and manganese homeostasis. Detrimental mutations of the ATP2C1 gene encoding SPCA1 cause Hailey-Hailey disease.
Knockdown of deleterious miRNA in progenitor cell-derived small extracellular vesicles enhances tissue repair in myocardial infarction

Mar 3, 2023 | science.org | Ananth Balashankar |Hyun-Ji Park |Ziv Epstein |Jessica Hoffman

LATEST NEWS AbstractSmall extracellular vesicles (sEVs) play a critical role in cardiac cell therapy by delivering molecular cargo and mediating cellular signaling. Among sEV cargo molecule types, microRNA (miRNA) is particularly potent and highly heterogeneous. However, not all miRNAs in sEV are beneficial. Two previous studies using computational modeling identified miR-192-5p and miR-432-5p as potentially deleterious in cardiac function and repair.

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Hyun-Ji Park

Articles

Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma

The catheterized bladder environment promotes Efg1- and Als1-dependent Candida albicans infection

Embedment of sensing elements for robust, highly sensitive, and cross-talk-free iontronic skins for robotics applications

Predicting the environmental fates of emerging contaminants: Synergistic effects in ozone reactions of nitrogen-containing alkenes

Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative

Social media: Why sharing interferes with telling true from false

A molecular framework for grain number determination in barley

Hierarchical approaches to Text-based Offense Classification

Cryo-EM structures of human SPCA1a reveal the mechanism of Ca2+/Mn2+ transport into the Golgi apparatus

Knockdown of deleterious miRNA in progenitor cell-derived small extracellular vesicles enhances tissue repair in myocardial infarction

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Emails

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