Jordan F. Hastings

Mar 3, 2023 | science.org | Ananth Balashankar |Hyun-Ji Park |Ziv Epstein |Jordan F. Hastings

AbstractGene expression noise is known to promote stochastic drug resistance through the elevated expression of individual genes in rare cancer cells. However, we now demonstrate that chemoresistant neuroblastoma cells emerge at a much higher frequency when the influence of noise is integrated across multiple components of an apoptotic signaling network.