Ian Reekie

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A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution - Nature Communications

Feb 19, 2024 | nature.com | Hamez Gacaferi |Jessica E. Ackerman |Peter Johnson |Ian Reekie |Moustafa Attar |Dylan Windell | +14 more

AbstractFrozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-inflammatory MERTKlowCD48+ macrophages and MERTK + LYVE1 + MRC1+ macrophages enriched for negative regulators of inflammation which co-exist in frozen shoulder capsule tissues.

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