Moustafa Attar

Feb 19, 2024 | nature.com | Hamez Gacaferi |Jessica E. Ackerman |Peter Johnson |Ian Reekie |Moustafa Attar |Dylan Windell | +14 more

AbstractFrozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-inflammatory MERTKlowCD48+ macrophages and MERTK + LYVE1 + MRC1+ macrophages enriched for negative regulators of inflammation which co-exist in frozen shoulder capsule tissues.

Apr 24, 2023 | nature.com | Yavuz F. Yazicioglu |Ciaran Sandhu |Barbara Kronsteiner |Moustafa Attar |Susanna J. Dunachie |Michael L. Dustin

AbstractGerminal center (GC) B cells undergo proliferation at very high rates in a hypoxic microenvironment but the cellular processes driving this are incompletely understood. Here we show that the mitochondria of GC B cells are highly dynamic, with significantly upregulated transcription and translation rates associated with the activity of transcription factor A, mitochondrial (TFAM).