Ignasi Puch-Giner

Apr 6, 2024 | nature.com | Maria Martinez-Molledo |Paola Bartoccioni |Ignasi Puch-Giner |Camille Stephan-Otto Attolini |Rafael Artuch |Lucia Diaz | +6 more

AbstractRecent cryoEM studies elucidated details of the structural basis for the substrate selectivity and translocation of heteromeric amino acid transporters. However, Asc1/CD98hc is the only neutral heteromeric amino acid transporter that can function through facilitated diffusion, and the only one that efficiently transports glycine and D-serine, and thus has a regulatory role in the central nervous system.