Ildar Gainetdinov

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A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila - Nature Cell Biology

Sep 18, 2023 | nature.com | Ildar Gainetdinov |Margaret R. Starostik |Jaclyn M Fingerhut |Peiwei Chen |Troy W Whitfield |Steven E. Jacobsen | +2 more

AbstractIn animals, PIWI-interacting RNAs (piRNAs) direct PIWI proteins to silence complementary targets such as transposons. In Drosophila and other species with a maternally specified germline, piRNAs deposited in the egg initiate piRNA biogenesis in the progeny. However, Y chromosome loci cannot participate in such a chain of intergenerational inheritance. How then can the biogenesis of Y-linked piRNAs be initiated?

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