Troy W Whitfield

Oct 9, 2024 | biorxiv.org | Rebecca Harris |Troy W Whitfield |Laura Blanton |Helen Skaletsky

AbstractThe origins of sex differences in human disease are elusive, in part because of difficulties in separating the effects of sex hormones and sex chromosomes. To separate these variables, we examined gene expression in four groups of trans- or cisgender individuals: XX individuals treated with exogenous testosterone (n=21), XY treated with exogenous estradiol (n=13), untreated XX (n=20), and untreated XY (n=15).

Jun 13, 2024 | journals.plos.org | Jaclyn M Fingerhut |Romain Lannes |Troy W Whitfield |Prathapan Thiru

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Fingerhut JM, Lannes R, Whitfield TW, Thiru P, Yamashita YM (2024) Co-transcriptional splicing facilitates transcription of gigantic genes. PLoS Genet 20(6): e1011241.

May 1, 2024 | cell.com | Anthony Flamier |George Bell |Annette Jun Diao |Troy W Whitfield

These cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work. These cookies do not store any personally identifiable information.

Sep 18, 2023 | nature.com | Ildar Gainetdinov |Margaret R. Starostik |Jaclyn M Fingerhut |Peiwei Chen |Troy W Whitfield |Steven E. Jacobsen | +2 more

AbstractIn animals, PIWI-interacting RNAs (piRNAs) direct PIWI proteins to silence complementary targets such as transposons. In Drosophila and other species with a maternally specified germline, piRNAs deposited in the egg initiate piRNA biogenesis in the progeny. However, Y chromosome loci cannot participate in such a chain of intergenerational inheritance. How then can the biogenesis of Y-linked piRNAs be initiated?

Aug 7, 2023 | biorxiv.org | Alexsia Richards |Andrew S. Khalil |Max Friesen |Troy W Whitfield

AbstractAlthough respiratory symptoms are the most prevalent disease manifestation of infection by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), nearly 20% of hospitalized patients are at risk for thromboembolic events. This prothrombotic state is considered a key factor in the increased risk of stroke, which has been observed clinically during both acute infection and long after symptoms have cleared.