Ilia Kurochkin

Apr 30, 2024 | nature.com | Hongkui Xiao |Isabel Ulmert |Ilia Kurochkin |Yinshui Chang |Urs Mörbe |Carlos-Filipe Pereira | +3 more

AbstractConventional dendritic cells (cDC) play key roles in immune induction, but what drives their heterogeneity and functional specialization is still ill-defined. Here we show that cDC-specific deletion of the transcriptional repressor Bcl6 in mice alters the phenotype and transcriptome of cDC1 and cDC2, while their lineage identity is preserved.