Ilia Minkin

2 months ago | biorxiv.org | Ilia Minkin |Steven Salzberg |Johns Hopkins

AbstractDespite many improvements over the years, the annotation of the human genome remains imperfect. The use of evolutionarily conserved sequences provides a strategy for selecting a high-confidence subset of the annotation. Using the latest whole genome alignment, we found that splice sites from protein-coding genes in the high-quality MANE annotation are consistently conserved across more than 350 species.