Steven Salzberg
Professor and Contributor at Forbes
Bloomberg Distinguished Professor of BME, CS, and Biostats at Johns Hopkins University, tennis player, blogger at Forbes: https://t.co/7SZhlbYPtn…
Articles
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3 weeks ago |
biorxiv.org | Caleb Hallinan |Hyun Ji |Steven Salzberg |Jean Fan
AbstractThe accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe binding to something other than the target gene, can distort a gene's true expression profile, making probe specificity essential for reliable transcriptomics.
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1 month ago |
biorxiv.org | Kuan-Hao Chao |Alan Mao |Anqi Liu |Steven Salzberg
AbstractThe SpliceAI deep learning system is currently one of the most accurate methods for identifying splicing signals directly from DNA sequences. However, its utility is limited by its reliance on older software frameworks and human-centric training data. Here we introduce OpenSpliceAI, a trainable, open-source version of SpliceAI implemented in PyTorch to address these challenges.
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1 month ago |
stevensalzberg.substack.com | Steven Salzberg
So here’s what’s going on. A team of scientists in Wuhan, China collected viruses from bats in remote caves, brought the viruses back to Wuhan, and started doing experiments. They discovered that one of the viruses, which they called HKU5-CoV-2, seems to be really good at infecting human cells. How exciting, they thought! After more experimentation to confirm how dangerous this virus was, they published their results in a prestigious scientific journal, Cell, just a couple of weeks ago.
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2 months ago |
biorxiv.org | Ilia Minkin |Steven Salzberg |Johns Hopkins
AbstractDespite many improvements over the years, the annotation of the human genome remains imperfect. The use of evolutionarily conserved sequences provides a strategy for selecting a high-confidence subset of the annotation. Using the latest whole genome alignment, we found that splice sites from protein-coding genes in the high-quality MANE annotation are consistently conserved across more than 350 species.
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2 months ago |
stevensalzberg.substack.com | Steven Salzberg
For 75 years, the U.S. has led the world in scientific research, most of it centered in our universities. Beginning in 1945 with a famous report by Vannevar Bush, the President’s science advisor, the U.S. has invested in science as a strategic effort to compete with its rivals and to build a better future.
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RT @KevinH_PhD: After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My lif…
Just wow. And it's only 124 light years away! Quite nearby, galactically speaking. I hope this result holds up https://t.co/kD6sngIDN3
Congrats to my colleague and collaborator @BenLangmead–our 2012 paper on Bowtie2, https://t.co/720zt4BEy1, ranks 29th on the most-cited papers of the 21st century https://t.co/R1cZzurYTK
