Steven Salzberg
Professor and Contributor at Forbes
Bloomberg Distinguished Professor of BME, CS, and Biostats at Johns Hopkins Univ., tennis player, https://t.co/xwqVB2TYkL, @stevensalzberg.bsky.social
Articles
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1 month ago |
stevensalzberg.substack.com | Steven Salzberg
I’ve been re-reading some things that I and others wrote about the dangers of creating deadly new viruses in the lab, “super bugs” as some have called them. Today I’m sharing some of my earlier commentary along with a fresh perspective, in light of the pandemic that the world suffered starting in 2020. Here’s what I wrote in late 2017. Thanks for reading Science and skepticism! Subscribe for free to receive new posts and support my work.
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2 months ago |
biorxiv.org | Caleb Hallinan |Hyun Ji |Steven Salzberg |Jean Fan
AbstractThe accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe binding to something other than the target gene, can distort a gene's true expression profile, making probe specificity essential for reliable transcriptomics.
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2 months ago |
biorxiv.org | Kuan-Hao Chao |Alan Mao |Anqi Liu |Steven Salzberg
AbstractThe SpliceAI deep learning system is currently one of the most accurate methods for identifying splicing signals directly from DNA sequences. However, its utility is limited by its reliance on older software frameworks and human-centric training data. Here we introduce OpenSpliceAI, a trainable, open-source version of SpliceAI implemented in PyTorch to address these challenges.
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Mar 10, 2025 |
stevensalzberg.substack.com | Steven Salzberg
So here’s what’s going on. A team of scientists in Wuhan, China collected viruses from bats in remote caves, brought the viruses back to Wuhan, and started doing experiments. They discovered that one of the viruses, which they called HKU5-CoV-2, seems to be really good at infecting human cells. How exciting, they thought! After more experimentation to confirm how dangerous this virus was, they published their results in a prestigious scientific journal, Cell, just a couple of weeks ago.
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Feb 20, 2025 |
biorxiv.org | Ilia Minkin |Steven Salzberg |Johns Hopkins
AbstractDespite many improvements over the years, the annotation of the human genome remains imperfect. The use of evolutionarily conserved sequences provides a strategy for selecting a high-confidence subset of the annotation. Using the latest whole genome alignment, we found that splice sites from protein-coding genes in the high-quality MANE annotation are consistently conserved across more than 350 species.
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RT @JohnsHopkins: NIH cuts are threatening life-changing research for families affected by SYNGAP1, a rare disorder that impacts brain deve…
I'm done with @usopen events after this "innovation" that basically destroys the mixed doubles event. The new format is 2 4-game sets, no-ad scoring, and a tiebreak if the mini-sets are split. The whole match might last 30 min! Ridiculous https://t.co/kOstXYD5md
Water is natural! – but that's not enough for French regulators, who want to sicken Perrier's customers with whatever bacteria or other contaminants might leech into the spring water https://t.co/B0XJYaQMu8
