Institut für Tropenmedizin

Jun 4, 2024 | link.springer.com | Médecins Sans Frontières |Sierra Leone |Institut für Tropenmedizin

AbstractSevere malaria is a life-threatening infection, particularly affecting children under the age of 5 years in Africa. Current treatment with parenteral artemisinin derivatives is highly efficacious. However, artemisinin partial resistance is widespread in Southeast Asia, resulting in delayed parasite clearance after therapy, and has emerged independently in South America, Oceania, and Africa.

Mar 18, 2024 | thelancet.com | Jeannot F. Zinsou |Institut für Tropenmedizin |Universität Tübingen |David J. Diemert

Summary A human hookworm vaccine is being developed to protect children against iron deficiency and anaemia associated with chronic infection with hookworms. Necator americanus aspartic protease-1 (Na-APR-1) and N americanus glutathione S-transferase-1 (Na-GST-1) are components of the blood digestion pathway critical to hookworm survival in the host.