Ioannis Kourtzelis

Oct 26, 2024 | biorxiv.org | Katie West |Stijn van Dongen |Ioannis Kourtzelis |Mags Gwynne

AbstractBeyond sex hormone and sex chromosome-driven mechanisms, little is known about cell intrinsic mediators of immune sexual dimorphism. We show that Malat1 is required for appropriate cytokine expression in female but not male Th2 cells. Malat1 deficiency impairs in vitro Th2 differentiation of naïve CD4+ T cells from female mice, characterised by transcriptome-wide effects and suppression of cytokine expression, particularly IL10.

Aug 29, 2024 | nature.com | Rongling Wang |Amanda Coutts |Rubén García-Martín |Matthias Blüher |Christopher J Schofield |Ioannis Kourtzelis | +8 more

AbstractEnhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte deficiency of the oxygen-sensor HIF-prolyl hydroxylase (PHD2) gene overcomes BAT dormancy at thermoneutrality. Adipocyte-PHD2-deficient mice maintain higher energy expenditure having greater BAT thermogenic capacity.