Irina Rais

1 month ago | biorxiv.org | Xianhe Li |Bruna Garcia |Silvia Reato |Irina Rais

AbstractAs large consumers of cellular metabolites, mitochondria are positioned to compete with invading microbes for the nutrients they require to grow. Yet, little is known of whether cells weaponize mitochondrial metabolism during infection. We found that the transcription factor ATF4 activated a mitochondrial metabolic defense based on the essential B vitamin folate.