Isabelle Gamache

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Cleavage of the V-ATPase associated prorenin receptor is mediated by PACE4 and is essential for growth of prostate cancer cells

Sep 14, 2023 | paperity.org | Amro H. Mohammad |Frédéric Couture |Isabelle Gamache |Owen Chen

PLOS ONE, Jul 2023 Phosphatase and tensin homolog (PTEN) mutation is common in prostate cancer during progression to metastatic and castration resistant forms. We previously reported that loss of PTEN function in prostate cancer leads to increased expression and secretion of the Prorenin Receptor (PRR) and its soluble processed form, the soluble Prorenin Receptor (sPRR). PRR is an essential factor required for proper assembly and activity of the vacuolar-ATPase (V-ATPase).
Cleavage of the V-ATPase associated prorenin receptor is mediated by PACE4 and is essential for growth of prostate cancer cells

Jul 18, 2023 | journals.plos.org | Amro H. Mohammad |Frédéric Couture |Université de Sherbrooke |Isabelle Gamache

Loading metrics Open Access Peer-reviewedResearch Article AbstractPhosphatase and tensin homolog (PTEN) mutation is common in prostate cancer during progression to metastatic and castration resistant forms. We previously reported that loss of PTEN function in prostate cancer leads to increased expression and secretion of the Prorenin Receptor (PRR) and its soluble processed form, the soluble Prorenin Receptor (sPRR).

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