Isidro Cortes-Ciriano

May 17, 2023 | nature.com | Jake Lee |Taek-Chin Cheong |Jose Espejo Valle-Inclan |Chong Chu |Isidro Cortes-Ciriano |Stephen J. Elledge | +3 more

AbstractFocal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure1,2,3 and the evolutionary trajectories4 of oncogene amplicons, their origin remains poorly understood. Here we show that focal amplifications in breast cancer frequently derive from a mechanism—which we term translocation–bridge amplification—involving inter-chromosomal translocations that lead to dicentric chromosome bridge formation and breakage.

Mar 21, 2023 | nature.com | Isidro Cortes-Ciriano |Jake Lee |Ruibin Xi |Dmitry Gordenin |Leszek J. Klimczak |Cheng-Zhong Zhang | +2 more

Author notesIsidro Cortés-CirianoPresent address: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UKA list of authors and their affiliations appears at the end of the paper. A list of authors and their affiliations appears online. Authors and AffiliationsDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USAIsidro Cortés-Ciriano, Jake June-Koo Lee, Dhawal Jain, Youngsook L. Jung, Isidro Cortés-Ciriano & Peter J.

Feb 27, 2023 | biorxiv.org | Jose Espejo Valle-Inclan |Isidro Cortes-Ciriano

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