Stephen J. Elledge

May 17, 2023 | nature.com | Jake Lee |Taek-Chin Cheong |Jose Espejo Valle-Inclan |Chong Chu |Isidro Cortes-Ciriano |Stephen J. Elledge | +3 more

AbstractFocal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure1,2,3 and the evolutionary trajectories4 of oncogene amplicons, their origin remains poorly understood. Here we show that focal amplifications in breast cancer frequently derive from a mechanism—which we term translocation–bridge amplification—involving inter-chromosomal translocations that lead to dicentric chromosome bridge formation and breakage.