Iván Martínez-Valbuena

Nov 22, 2024 | biorxiv.org | Masahiro Enomoto |Iván Martínez-Valbuena |Shelley L. Forrest |Xiaoxiao Xu

AbstractThe ordered assembly of a-synuclein protein into filaments encoded by SNCA characterizes neurodegenerative diseases called synucleinopathies. Lewy body disease (LBD) shows predominantly neuronal a-synuclein pathology and multiple system atrophy (MSA) predominantly oligodendrocytic a-synuclein pathology affecting subcortical brain structures.

Jan 12, 2024 | onlinelibrary.wiley.com | Iván Martínez-Valbuena

Neurodegenerative diseases are a pathologically, clinically, and genetically diverse group of disorders that at present lack any disease-modifying therapies [1]. Pathologically, these disorders, collectively referred to as proteinopathies, are characterized by disease-specific protein aggregates in neurons and/or glia.