Masahiro Enomoto

Nov 22, 2024 | biorxiv.org | Masahiro Enomoto |Iván Martínez-Valbuena |Shelley L. Forrest |Xiaoxiao Xu

AbstractThe ordered assembly of a-synuclein protein into filaments encoded by SNCA characterizes neurodegenerative diseases called synucleinopathies. Lewy body disease (LBD) shows predominantly neuronal a-synuclein pathology and multiple system atrophy (MSA) predominantly oligodendrocytic a-synuclein pathology affecting subcortical brain structures.

May 15, 2024 | onlinelibrary.wiley.com | Masahiro Enomoto |Christopher Marshall |Mitsuhiko Ikura |Ningdi F. Liu

1 INTRODUCTION RAF kinase activation is a complex regulatory step within the fundamental RAS-RAF-MEK-ERK (RAS-MAPK) pathway that controls growth, differentiation, division, and proliferation. Five RAF family members are present in vertebrates: ARAF, BRAF and CRAF (RAF1) in addition to the pseudokinases KSR1/2.