Ivan Spicka

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Allocation and validation of the second revision of the International Staging System in the ICARIA-MM and IKEMA studies - Blood Cancer Journal

Mar 14, 2023 | nature.com | Paul Richardson |Aurore Perrot |Joseph R. Mikhael |Thomas Martin |Meral Beksac |Ivan Spicka | +2 more

AbstractThe International Staging System for multiple myeloma recently underwent a second revision (R2-ISS) to include gain/amplification of 1q21 and account for the additive prognostic significance of multiple high-risk features. The phase 3 ICARIA-MM (isatuximab–pomalidomide–dexamethasone vs. pomalidomide–dexamethasone) and IKEMA (isatuximab–carfilzomib–dexamethasone vs.

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