J. Kenneth Baillie

Jan 17, 2025 | nature.com | Long Châu |Chen-Hsuin Lee |Christine Tait-Burkard |Sarah Fletcher |Louise Gibbard |J. Kenneth Baillie | +1 more

AbstractAnimal models that accurately reflect COVID-19 are vital for understanding mechanisms of disease and advancing development of improved vaccines and therapeutics. Pigs are increasingly recognized as valuable models for human disease due to their genetic, anatomical, physiological, and immunological similarities to humans, and they present a more ethically viable alternative to non-human primates.

Apr 8, 2024 | nature.com | Claudia Efstathiou |Shona C Moore |Jose Nunag |Amisha Singapuri |Marco Sereno |Linzy Houchen-Wolloff | +12 more

AbstractOne in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID.

Jan 2, 2024 | jamanetwork.com | Yanshan Zhu |Flavia Almeida |J. Kenneth Baillie |Asha C Bowen

Errors in Article Pediatric COVID-19 Severity Over the Course of the Pandemic Yanshan Zhu, MMed; Flávia Jacqueline Almeida, MD; J. Kenneth Baillie, PhD; Asha C. Bowen, PhD; Philip N. Britton, PhD; Martin Eduardo Brizuela, MD; Danilo Buonsenso, PhD; David Burgner, PhD; Keng Yih Chew, PhD; Kulkanya Chokephaibulkit, MD; Cheryl Cohen, PhD; Stephania A. Cormier, PhD; Nigel Crawford, PhD; Nigel Curtis, PhD; Camila G. A. Farias, MD; Charles F.

Feb 16, 2023 | nature.com | J. Kenneth Baillie

Understanding the impact of comorbidity in COVID-19 has two broad purposes—it enables prioritization for interventions such as preventive measures, vaccination and early treatment, and it may deepen understanding of the underlying biology of the disease. These principles are reflected in public-health guidance that prioritizes some groups for vaccination, and clinical guidance to use antivirals to prevent hospitalization in people with specific comorbidities.