J. Michelle Kahlenberg

Jan 16, 2025 | nature.com | Allison C. Billi |J. Michelle Kahlenberg

While the skin is among the most commonly affected organ systems in systemic lupus erythematosus (SLE), the role of the skin in driving disease onset remains unresolved. In their recent work, Tian et al. reported that PPARγ deficiency in keratinocytes (KCs) leads to epidermal hypersecretion of type I IFN. The resulting IFN-rich environment activates local dendritic cells (DCs), which in turn activate autoreactive T cells to precipitate SLE-like autoimmune disease [1].

May 31, 2024 | healio.com | J. Michelle Kahlenberg |Rebecca Forand |Kristen Dowd

Read more You've successfully added Skin Care to your alerts. You will receive an email when new content is published. Click Here to Manage Email Alerts We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. CLEVELAND — While new treatments for cutaneous lupus are on the horizon, sunscreen remains the best way to offset effects, according to J. Michelle Kahlenberg, MD, PhD.