Jacob Elkahal

Aug 25, 2024 | nature.com | Gal Aviel |Jacob Elkahal |Kfir Baruch Umansky |David Kain |Tali Shalit |Shoval Miyara | +2 more

AbstractMyocardial injury may ultimately lead to adverse ventricular remodeling and development of heart failure (HF), which is a major cause of morbidity and mortality worldwide. Given the slow pace and substantial costs of developing new therapeutics, drug repurposing is an attractive alternative. Studies of many organs, including the heart, highlight the importance of the immune system in modulating injury and repair outcomes.

Jun 13, 2024 | nature.com | Kfir Baruch Umansky |Shoval Miyara |Avital Sarusi-Portuguez |Yoseph Addadi |Elly M. Tanaka |Rachel Sarig | +1 more

AbstractSenescence plays a key role in various physiological and pathological processes. We reported that injury-induced transient senescence correlates with heart regeneration, yet the multi-omics profile and molecular underpinnings of regenerative senescence remain obscure.