Jacob Stern

1 month ago | biorxiv.org | Jacob Stern |Anandsukeerthi Sandholu |Stefan T. Arold |Siba Alharbi

AbstractA general method for designing proteins with high conformational specificity is desirable for a variety of applications, including enzyme design and drug target redesign. To assess the ability of algorithms to design for conformational specificity, we introduce MotifDiv, a benchmark dataset of 200 conformational specificity design challenges. We also introduce CSDesign, an algorithm for designing proteins with high preference for a target conformation over an alternate conformation.

May 16, 2024 | theatlantic.com | Jacob Stern

Remember when streaming was supposed to let us watch whatever we want, whenever we want, for a sliver of the cost of cable? Well, so much for that. In recent years, streaming has gotten confusing and expensive as more services than ever are vying for eyeballs. It has done the impossible: made people miss the good old-fashioned cable bundle. Now the bundles are back. Last week, Disney and Warner Bros.

May 16, 2024 | newsbreak.com | Jacob Stern

Remember when streaming was supposed to let us watch whatever we want, whenever we want, for a sliver of the cost of cable? Well, so much for that. In recent years, streaming has gotten confusing and expensive as more services than ever are vying for eyeballs. It has done the impossible: made people miss the good old-fashioned cable bundle. Now the bundles are back. Last week, Disney and Warner Bros.

May 2, 2024 | theatlantic.com | Jacob Stern

Before Pauline Kael was Pauline Kael, she was still very much Pauline Kael. When her first essay for The Atlantic ran in November 1964, she had not yet lost it at the movies. She had not yet become Pauline Kael, the vaunted and polarizing film critic for The New Yorker. She had not yet inspired a movement of imitators, the “Paulettes,” or established herself as one of the most influential film writers ever.

May 1, 2024 | newsbreak.com | Jacob Stern

The robot is shaped like a human, but it sure doesn’t move like one. It starts supine on the floor, pancake-flat. Then, in a display of superhuman joint mobility, its legs curl upward from the knees, sort of like a scorpion tail, until its feet settle firmly on the floor beside its hips. From there, it stands up, a swiveling mass of silver limbs. The robot’s ring-light heads turns a full 180 degrees to face the camera, as though possessed. Then it lurches forward at you.