
Stefan T. Arold
Articles
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1 month ago |
biorxiv.org | Jacob Stern |Anandsukeerthi Sandholu |Stefan T. Arold |Siba Alharbi
AbstractA general method for designing proteins with high conformational specificity is desirable for a variety of applications, including enzyme design and drug target redesign. To assess the ability of algorithms to design for conformational specificity, we introduce MotifDiv, a benchmark dataset of 200 conformational specificity design challenges. We also introduce CSDesign, an algorithm for designing proteins with high preference for a target conformation over an alternate conformation.
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