Jae Lee

Dec 27, 2024 | nature.com | Jae Lee

AbstractUltrasound (US) is a widely used technique for liver disease but has limitations in distinguishing tumors. This study evaluates the clinical efficacy of fluctuational imaging (FLI), a new US method that detects the fluttering sign in liver tumors. We conducted a prospective exploratory study with 120 participants diagnosed with liver tumors through histopathology or standard imaging.

Jul 8, 2024 | analyticalsciencejournals.onlinelibrary.wiley.com | Kyuhee Cho |Jae Lee

Chinese hamster ovary (CHO) cell line is the most widely used cell line for biopharmaceutical production. Therefore, generation of a stable recombinant CHO (rCHO) cell line with high productivity is necessary for the production of recombinant therapeutic proteins, which account for the largest proportion of biologics (Walsh & Walsh, 2022). Traditionally, stable cell line development is based on random integration (RI) of the transgene, subsequent selection, and large-scale clone screening.

Jun 24, 2024 | nature.com | Jae Lee

AbstractEvaluating fluid responsiveness with dynamic parameters is recommended for fluid management. However, in hemodynamically stable patients who are breathing spontaneously, accurately measuring stroke volume variation via echocardiography and passive leg raising is challenging due to subtle SV changes. This study aimed to identify normal SV changes in healthy volunteers and evaluate the precision of hemodynamic parameters in screening mild hypovolemia in patients.

May 27, 2024 | onlinelibrary.wiley.com | Dan Park |Jae Lee |sung kim |Hyun J. Kim

1 INTRODUCTION Turbinate reduction surgery has emerged as a principal therapeutic strategy for the management of chronic hypertrophic rhinitis and allergic rhinitis, substantiated by evidence demonstrating long-term efficacy.1 The performance of this surgical intervention markedly increased from 27,670 procedures in the United States from 2000 to 2015.2 Nevertheless, up to 10% of patients undergoing turbinate surgery may develop secondary atrophic rhinitis (AR) due to excessive disruption of...

May 14, 2024 | nature.com | Jae Lee

AbstractPlasma N-terminal prohormone of brain natriuretic peptide (NT-proBNP) level is primarily used as a biomarker for left ventricular (LV) dysfunction. It is influenced by various conditions, such as myocardial strain and situations affecting the clearance of NT-proBNP, including sepsis and shock. In this study, we investigated the appropriateness of NT-proBNP as a prognostic factor for septic shock.