Jae Woo Jung

Apr 26, 2023 | nature.com | Michael D. Neinast |Cholsoon Jang |Jae Woo Jung |Jessie E. Axsom |Marc R. Bornstein |Chelsea L. Thorsheim | +4 more

AbstractElevated levels of plasma branched-chain amino acids (BCAAs) have been associated with insulin resistance and type 2 diabetes since the 1960s. Pharmacological activation of branched-chain α-ketoacid dehydrogenase (BCKDH), the rate-limiting enzyme of BCAA oxidation, lowers plasma BCAAs and improves insulin sensitivity. Here we show that modulation of BCKDH in skeletal muscle, but not liver, affects fasting plasma BCAAs in male mice.