Cholsoon Jang

Oct 25, 2023 | nature.com | Rui Li |Lihua Zhu |Christopher Ashwood |Karl Simin |Cholsoon Jang |Jessica B. Spinelli | +1 more

AbstractIdentifying metabolic steps that are specifically required for the survival of cancer cells but are dispensable in normal cells remains a challenge1. Here we report a therapeutic vulnerability in a sugar nucleotide biosynthetic pathway that can be exploited in cancer cells with only a limited impact on normal cells.

Oct 25, 2023 | nature.com | Rui Li |Lihua Zhu |Christopher Ashwood |Karl Simin |Cholsoon Jang |Jessica B. Spinelli | +1 more

AbstractIdentifying metabolic steps that are specifically required for the survival of cancer cells but are dispensable in normal cells remains a challenge1. Here we report a therapeutic vulnerability in a sugar nucleotide biosynthetic pathway that can be exploited in cancer cells with only a limited impact on normal cells.

Apr 26, 2023 | nature.com | Michael D. Neinast |Cholsoon Jang |Jae Woo Jung |Jessie E. Axsom |Marc R. Bornstein |Chelsea L. Thorsheim | +4 more

AbstractElevated levels of plasma branched-chain amino acids (BCAAs) have been associated with insulin resistance and type 2 diabetes since the 1960s. Pharmacological activation of branched-chain α-ketoacid dehydrogenase (BCKDH), the rate-limiting enzyme of BCAA oxidation, lowers plasma BCAAs and improves insulin sensitivity. Here we show that modulation of BCKDH in skeletal muscle, but not liver, affects fasting plasma BCAAs in male mice.