Jainu Ajit

Apr 17, 2024 | biorxiv.org | Jainu Ajit |Qing Chen |Matthew Rosenberger |Trevor Ung

AbstractTrained immunity improves disease resistance by strengthening our first line of defense, the innate immune system. Innate immune cells, predominantly macrophages, are epigenetically and metabolically rewired by β-glucan, a fungal cell wall component, to induce trained immunity. These trained macrophages exhibit increased co-stimulatory marker expression and altered cytokine production. Signaling changes from antigen-presenting cells, including macrophages, polarize T-cell responses.

Mar 27, 2024 | biorxiv.org | Qing Chen |Ani Solanki |Jingjing Shen |Jainu Ajit

AbstractTrained immunity refers to the non-specific innate immune memory response triggered by the epigenetic and metabolic rewiring of innate immune cells. A strengthened innate immune system significantly improves disease resistance. However, very few trained immunity-inducing molecules have been identified. Almost all molecules for training are primarily immunogenic and then subsequently induce training.