Matthew Rosenberger

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Articles

Identification of CDK4/6 Inhibitors as Small Molecule NLRP3 Inflammasome Activators that Facilitate IL-1β Secretion and T Cell Adjuvanticity

Aug 20, 2024 | dx.doi.org | Adam Weiss |Matthew Rosenberger |Jeremiah Kim |Jingjing Shen
Identification of CDK4/6 Inhibitors as Small Molecule NLRP3 Inflammasome Activators that Facilitate IL-1β Secretion and T Cell Adjuvanticity

Aug 20, 2024 | pubs.acs.org | Adam Weiss |Matthew Rosenberger |Jeremiah Kim |Jingjing Shen
β-glucan induced trained immunity enhances antibody levels in a vaccination model in mice

Apr 17, 2024 | biorxiv.org | Jainu Ajit |Qing Chen |Matthew Rosenberger |Trevor Ung

AbstractTrained immunity improves disease resistance by strengthening our first line of defense, the innate immune system. Innate immune cells, predominantly macrophages, are epigenetically and metabolically rewired by β-glucan, a fungal cell wall component, to induce trained immunity. These trained macrophages exhibit increased co-stimulatory marker expression and altered cytokine production. Signaling changes from antigen-presenting cells, including macrophages, polarize T-cell responses.

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