Jakub Mieczkowski

Sep 17, 2024 | biorxiv.org | Devin King |Dakota McCoy |Adrian Perdyan |Jakub Mieczkowski

AbstractThe p53 tumor suppressor is an indispensable regulator of DNA damage responses that accelerates carcinogenesis when mutated. In this report, we uncover a new mechanism by which p53 maintains genomic integrity in the absence of canonical DNA damage response activation. Specifically, loss of p53 dramatically alters chromatin structure at the nuclear periphery, allowing increased transmission of an environmental carcinogen, ultraviolet (UV) radiation, into the nucleus.

Jun 11, 2024 | nature.com | Christopher Mason |James Green |Jordan Baechle |Mathias Basner |Susan Bailey |Joseph Borg | +34 more

AbstractThe recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a ‘second space age’.